Follicular mucinosis is a term that encompasses three related entities. Alopecia mucinosa, Urticaria-like follicular mucinosis, and cutaneous lymphoma related. On hair-bearing skin (e.g. scalp), overlying alopecia is notable, hence the term “ alopecia mucinosa” (see Figure 5). Plaques are often composed of densely. Alopecia mucinosa is a skin disorder that generally presents, but not exclusively, as erythematous plaques or flat patches without hair primarily on the scalp.
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This hair loss is reversible in the early stages, but once the disease advances, the hair follicles are destroyed, and Scarring alopecia occurs. Follicular mucinosis as a histological finding by itself, does not denote a specific clinico-pathological entity and has been described as an incidental finding in several unrelated conditions like angiolymphoid hyperplasia,[ 56 ] familial reticuloendotheliosis,[ 7 ] spongiotic dermatitis,[ 1 ] and in diffuse papular and eczematous eruptions.
She completed 6 months of MDT in Decemberat which time the lesion had cleared completely with regrowth of all hair [ Figure 1b ]. Accessed December 31st, Acrokeratosis paraneoplastica of Bazex Acroosteolysis Bubble hair deformity Disseminate and recurrent infundibulofolliculitis Erosive pustular dermatitis of the scalp Erythromelanosis follicularis faciei mucinlsa colli Hair casts Hair follicle nevus Intermittent hair—follicle dystrophy Keratosis pilaris atropicans Kinking hair Koenen’s tumor Lichen planopilaris Lichen spinulosus Loose anagen syndrome Menkes kinky hair syndrome Monilethrix Parakeratosis pustulosa Pili Pili annulati Pili bifurcati Pili multigemini Pili pseudoannulati Pili torti Pityriasis amiantacea Plica neuropathica Poliosis Rubinstein—Taybi syndrome Setleis syndrome Traumatic anserine folliculosis Trichomegaly Trichomycosis axillaris Trichorrhexis Trichorrhexis invaginata Trichorrhexis nodosa Trichostasis spinulosa Uncombable hair syndrome Wooly hair Wooly hair nevus.
Given the association with CTCL, as well as much rarer associations with other hematologic malignancies e. There is no proven effective treatment for alopecia mucinosa.
Dose, frequency, and duration of therapy is indicated where available and is based on published literature.
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This page was last edited on 21 Juneat In sum, we present three cases of Alopecia mcuinosa, who presented with single lesions on the face, had follicular mucinosis on biopsy and who healed rapidly and completely with initiation of antileprosy treatment. Alopecia mucinosa has been divided into the primary or idiopathic variety and the secondary type associated with cutaneous T cell lymphoma. Three cases with single lesion of Alopecia mucinosa follicular mucinosis were treated with antileprosy treatment and showed rapid and complete resolution of the lesions with no recurrence on extended follow-up.
Topical corticosteroids mid to high potency —response expected within 3 aloecia Tretinoin 0. The patient completed all six doses of ROM, and has not had recurrence in the ensuing 1 year. Clonal FM may regress completely. Analysis of lesional skin for T-cell clonality using PCR for T cell receptor[TCR] gene rearrangements should be considered in patients with known or suspected FM, but is not required for diagnosis.
Contraindicated in patients with glucosephosphate dehydrogenase deficiency. Lever’s Histopathology of the skin. Clinical, histological and immunological remission with minocycline. Guitart, J, Magro, C. Minocycline mg orally, twice daily; response noted within 6 months; begin to taper slowly over months after lesions have cleared.
Click here for patient related inquiries. Infobox medical condition new All stub articles. Introduction What was known?
Case Reports Case 1 A year-old boy presented in Septemberwith a hypopigmented and hypoaesthetic shiny patch on the left cheek of few months duration. A detailed morphologic and immunopathologic study.
Alopecia Mucinosa [Accessed 24 August ]. Self-skin examination New smartphone apps to check your skin Learn more Sponsored content. Therefore it is too much of coincidence to consider that the response in mucinosaa patients was due to natural remission, and it is most likely that it was the oral treatment that brought about healing of the lesions.
All our cases presented with single lesions which demonstrated hypoesthesia. A reaction pattern in follicular epithelium.
Some papers[ 411 ] have shown good response of follicular mucinosis to minocycline, however, contrary results with very minimal or no improvement has also been reported in patients with Alopecia mucinosa who were treated with minocycline for more than 3 months. A month later the patch had enlarged minimally, the surface was dry and showed follicular prominences, however, no erythema was seen [ Figure 1a ].
Pathology Outlines – Alopecia mucinosa
Alopecia mucinosa — codes and concepts open. Lesions are often asymptomatic but may itch or burn; they develop over weeks or months not days. At this stage it is pertinent to reflect on the vagaries and irony of the practice of medicine. It is characterised by bald patches of skin in which hair follicles are prominent. Usually, primary and acute alopecia mucinosa occurring in children resolves spontaneously.
A retrospective analysis of histopathology of 64 cases of lepra reactions. Alopecia mucinosa is diagnosed by its clinical appearance and supported by histopathological findings on biopsy:. Follicular mucinosis presenting as an acneiform eruption: The biopsy showed a moderately dense superficial and mid perivascular infiltrate of lymphocytes with occasional eosinophils without any granulomas in the sections.
The authors suggest that in regions endemic for leprosy, such as India, single lesion Alopecia mucinosa on the face in children and young adults should be given antileprosy treatment.