Time Series: Building statistical models with NONMEM is more robust than conventional RMANOVA in assessing time series data. Examples of time series data. From: Steven Shafer > Date: Mon, 14 Feb Dear Colleagues: You will be pleased to. From: Steven Shafer > Date: Fri, 6 Jan Dear Colleagues: This is the second.

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Introduction to Survival Analysis Procedures. In the workshops registrants who brought their own data were typically able to assemble datasets nonme using the R code learned in the R workshopand analyze their data using the PLT Tools diagnostic graphics e.

The Power and Sample Size Application. Introduction to Categorical Data Analysis Procedures. Introduction to Power and Sample Size Analysis.

Statistical Decision Theory and Bayesian Analysis. Introduction to Discriminant Procedures. Introduction to Nonparametric Analysis. Statistical Analysis with Missing Data.

Fisher/Shafer NONMEM Workshop

Registrants were provided with a comprehensive set of graphical tools programmed in the R and S Plus statistical languages to create high-quality diagnostic and analysis plots, as well as a powerful graphical user interface for NONMEM to facilitate rapid analysis of clinical trial data.


The workshop includeed an extensive set of example problems ranging from simple didactic examples to demonstrate basic concepts to complex examples from the instructors’ own experience. A Tribute to D. Shafer Pharmacodynamic Models Tuesday Afternoon: Hierarchical Modeling and Analysis for Spatial Data. Fisher Simulation and Validation Wednesday Morning: Shared Concepts and Nonme. A First Course in Numerical Analysis.

Shafer Population Approaches, Fixed vs. Introduction to Multivariate Procedures.

The MCMC Procedure

Pharmacokinetic and Pharmacodynamic Data Analysis: The fully functional PLT Tools is freely available for download. Concepts, Algorithms, and Applications. Sharer to Analysis of Variance Procedures. Technical report, Science Applications Inc.

Group Sequential Design and Analysis. Introduction to Survey Sampling and Analysis Procedures. Introduction to Scoring, Standardization, and Ranking Procedures. Introduction to Regression Procedures.

Survey Sampling and Analysis. Introduction to Mixed Modeling Procedures.

Recent Developmentsedited by Nnmem. Using the Output Delivery System. PLT Tools provides a graphical interface for controlling and organizing NONMEM analyses, comprehensive graphics to analyze model results, powerful features including visual predictive check, log likelihood profiling, bootstrap analysis, and jackknife model validation.

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The Bethesda course was our 17th and last workshop. It also has tools for comprehensive auditability and automated report generation.

Table of Contents Topics Credits and Acknowledgments. We thank the hundreds of students nnonmem have made this course one of the highlights of our lives for the course duration.

PLT Tools: About Us

The Four Types of Estimable Functions. Customizing the Kaplan-Meier Survival Plot. Introduction to Clustering Procedures. Power and Sample Size. Introduction to Bayesian Analysis Procedures.