Em sua maioria, os gliomas de pineal são astrocitomas de baixo grau, sendo que o seu correspondente maligno, glioblastoma multiforme, é o mais comum e. Estudos relacionados à regulação do processo de apoptose em glioblastoma ( GBM), o glioma maligno mais comum, são poucos, e o melhor conhecimento da . Il gliosarcoma è una variante istologica del glioblastoma caratterizzata da una struttura tessutale bifasica, con aree che mostrano alternativamente.

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Pyk2 and FAK differentially regulate progression of the cell cycle.

There are limitations in the use of the above-discussed models. Loss of heterozygosity on chromosome 10 is more extensive in primary de novo than in secondary glioblastomas. Further analysis are need to be done to evaluate the therapeutic potential of apoptotic and anti-apoptotic proteins in the treatment of GBM. Abstract The ongoing characterization of the genetic and epigenetic alterations in the gliomas has already improved the classification of these heterogeneous tumors and enabled the development of rodent models for analysis of the molecular pathways underlying their proliferative and invasive behavior.

Taken together, these studies suggest that alterations in neural progenitor cells probably give rise to at least some high-grade gliomas.

Mol Cell Biol ;5: Expression of oligodendrocyte progenitor cell antigens by gliomas: Because these tumors are usually included within series of pineal region tumors it is difficult to study the clinical and imaging features of these cases Table 1. Grade I tumors typically have a good prognosis and more frequently occur in children 58and Grade II tumors are characterized on histologic examination by hypercellularity: Free Radic Biol Med ; Other studies of proteins related to the intrinsic and extrinsic pathway of apoptosis are required to provide additional information of this mechanism in GBMs.


The low-grade astrocitomas would appear on CT-scan as iso or hypodense lesions with heterogeneous moderate contrast enhancement.

Glioblastoma multiforme of the pineal region: case report

Services on Demand Journal. Homolog of the scavenger receptor cysteine-rich SRCR superfamily.

Pathology and genetics of tumours of the nervous system, World Health Organization classification of tumours. The phosphorylation of EphB2 receptor regulates migration and invasion of human glioma cells. Menu di navigazione Strumenti personali Accesso non effettuato discussioni contributi registrati entra. Thus, proteases act in concert with cell-surface receptors and downstream signaling molecules to promote glioma cell invasion Genetic pathways to glioblastoma: The germinomas would appear hyperdense on CT-scan, with a strong contrast enhencement.

Additional tumors arising from the glial components of the pineal gland include ganglioneuroma, ganglioglioma, chemodectoma, meningeoma, and gliomas, more frequently low-grade astrocytomas. Nat Clin Pract Oncol.

Caspase-3 and Bcl-2 expression in glioblastoma: an immunohistochemical study

Clinicopathologic features of pripary and postirradiation cerebral gliosarcoma. According to World Health Organization WHOthese tumors are classified based on histological and clinical criteria in: The CT-scan examination showed a rounded hypodense ill-defined lesion at the pineal region with extension to the right thalamus.

One disadvantage of human xenograft models is that most human glioma cell lines are not invasive when propagated in vivo — Glioblastoma multiforme, the most aggressive and common brain tumor, is glima rare at this location with only few cases reported.

Growth factor receptors and cell-adhesion receptors typically rapidly activate focal adhesion kinase FAKa cytoplasmic nonreceptor tyrosine tlioma. This limitation has been overcome by propagating primary human GBM tumors in the nude mouse either subcutaneously or intracerebrally instead of in culture; when these tumors are propagated in vivo, the genetic alterations found in the patients biopsy are retained Demuth T, Berens ME. I contenuti hanno solo fine illustrativo e non sostituiscono il parere medico: Stimulates cell proliferation and migration due to an autocrine loop.


The pineocytomas are radiologically indistinguishable from the benign pineal cysts. Study on aneuploidy and p53 mutations in astrocytonias. Dissecting tumor maintenance requirements using bioluminescence imaging of cell proliferation in a mouse glioma model.


Analysis of 1p, 19q, 9p, and 10q as prognostic markers for high-grade astrocytomas using fluorescence in situ hybridization on tissue microarrays from radiation therapy oncology group trials.

One model uses the somatic gene-transfer technology in which retrovirally expressed PDGF-B is injected intracranially into newborn mice, resulting in PDGF-B expression in neural progenitor cells and the induction mlaigno oligodendroglioma tumors Intracerebral transplantation of a human glioma line in immunosuppressed rats.

Visite Leggi Modifica Modifica wikitesto Cronologia. Apoptosis is a programmed cell death with significant role in development and homeostasis of multicellular organisms.

The main aspects for this differentiation are discussed below.

These tumors usually develop in the first two decades of life and predominate in males 1,4,