;(21)– [PubMed]; Constantopoulos A, Karpathios T, Nicolaidou P, Maounis F, Matsaniotis N. Lazy-leukocyte syndrome. A case report . The lazy leukocyte syndrome was first described by Miller et al. in in two children with recurrent infection. They had normal humoral and cellular immunity . – LAZY LEUKOCYTE SYNDROME. LAZY LEUKOCYTE SYNDROME. Clinical Synopsis Toggle Dropdown. Inheritance. -? Autosomal dominant new.

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Pathology of chemotaxis and random mobility. Transient ‘lazy-leukocyte’ syndrome during infancy.

We are determined to keep this website freely accessible. While the OMIM database is open to the public, users seeking information about a personal medical or genetic condition are urged to consult with a qualified physician for diagnosis and for answers to personal questions.


A characteristic abnormality of actin distribution in neutrophils was demonstrated. Single cases were reported by Costanopoulos et al. Looking For More References? Autosomal dominant new mutations.

Leukocyte phagocytosis and bactericidal activity were normal. Miller knew of 4 other cases. Please consider making a donation now and again in the future. Both random mobility and chemotactic function were defective. A bonus to all MIMmatch users is the option to sign up for updates on new gene-phenotype relationships. Expert curators review the literature and organize it to facilitate your work. The year-old proposita had neutropenia and an illness suggestive of persistent Epstein-Barr virus infection.

The same abnormality probably leads to impaired deformability of neutrophils so that release of newly formed neutrophils from the bone marrow is reduced.

Lazy leukocyte syndrome | definition of lazy leukocyte syndrome by Medical dictionary

OMIM is intended for use primarily by physicians and other professionals concerned with genetic disorders, by genetics researchers, and by advanced students in science and medicine. A severe neutropenia was found. Unfortunately, it is not free to produce. A poor neutrophil response was obtained upon stimulation with both epinephrine and endotoxin, kazy well as upon induced inflammation by the Rebuck skin window technique.


Relative to the genetics and the possibility that these cases represent new dominant mutations, parental age data would be of interest. Mobilization of leukocytes after exercise oeukocyte defective. A new disorder of neutrophil function. Bone marrow studies showed normal numbers of mature, morphologically normal neutrophils.

Lazy leukocyte syndrome.

Skin window mobilization test and chemotaxis were normal. Synfrome Synopsis Toggle Dropdown. None is familial and no parental consanguinity is known. The syndrome is distinguished from neutrophil chemotactic deficiencies by the coexistence of defective random motility and peripheral blood neutropenia with normal bone marrow granulocyte reserve.